| Dimensions |
| Length | Length5,116 mm–5,266 mm | Length5,179 mm–5,470 mm |
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| Width | Width1,899 mm | Width1,921 mm–1,954 mm |
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| Height | Height1,496 mm | Height1,503 mm–1,510 mm |
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| Wheelbase | Wheelbase3,035 mm–3,165 mm | Wheelbase3,106 mm–3,396 mm |
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| Ground clearance | Ground clearance120 mm–130 mm | Ground clearance110 mm–120 mm |
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| Trunk volume | Trunk volume510 l–530 l | Trunk volume305 l–550 l |
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| Curb weight | Curb weight1,935 kg–2,185 kg | Curb weight2,040 kg–2,595 kg |
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| Fuel tank | Fuel tank70 l–90 l | Fuel tank50 l–90 l |
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| Engines |
| Production years | Production years2013–2020 | Production years2020–present |
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| Body type | Body typeSedan | Body typeSedan |
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| Number of engines | Number of engines10 | Number of engines11 |
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| Power | Power170–463 kW (231–630 hp) | Power210–590 kW (286–802 hp) |
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| Displacement (l) | Displacement (l)2.1–6.0 | Displacement (l)2.9–6.0 |
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| Fuel | FuelDiesel, Petrol, Hybrid | FuelDiesel, Petrol, Plug-in hybrid |
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| Gearbox | GearboxAutomatic | GearboxAutomatic |
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| Drivetrain | DrivetrainRear-wheel, All-wheel (4x4) | DrivetrainRear-wheel, All-wheel (4x4) |
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| Lowest consumption | Lowest consumption4.4 l/100 km · S 300 BlueTEC HYBRID | Lowest consumption1.2 l/100 km · S 450 e |
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| Best 0–100 km/h | Best 0–100 km/h4 s · S 63 AMG 4MATIC | Best 0–100 km/h3.3 s · S 63 AMG E Performance |
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| Top speed | Top speed250 km/h | Top speed290 km/h |
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| Trim levelsStandard · Base |
| Items in the base trim | Items in the base trim37 · Standard | Items in the base trim27 · Base |
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| Items in the top trim | Items in the top trim39 · Lang | Items in the top trim38 · Exclusive |
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| Equipment · Comfort13 · 7 |
| Climate Control, 2-zone | Climate Control, 2-zone | Climate Control, 2-zone |
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| Rear Air Vents | Rear Air Vents | Rear Air Vents |
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| Cruise Control | Cruise Control— | Cruise Control |
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| Adaptive Cruise Control | Adaptive Cruise Control | Adaptive Cruise Control— |
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| Automatic Parking | Automatic Parking | Automatic Parking— |
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| Rear-view Camera | Rear-view Camera | Rear-view Camera |
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| Electric Steering Wheel Adjustment | Electric Steering Wheel Adjustment | Electric Steering Wheel Adjustment— |
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| Front Power Windows | Front Power Windows | Front Power Windows— |
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| Rear Power Windows | Rear Power Windows | Rear Power Windows— |
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| Power Steering | Power Steering— | Power Steering |
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| Keyless Entry | Keyless Entry | Keyless Entry— |
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| Push-button Start | Push-button Start | Push-button Start |
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| Digital Instrument Cluster | Digital Instrument Cluster | Digital Instrument Cluster |
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| Power-adjustable mirrors | Power-adjustable mirrors | Power-adjustable mirrors— |
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| Air suspension | Air suspension | Air suspension— |
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| Equipment · Interior6 · 3 |
| Leather | Leather | Leather |
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| Electric Front Seats | Electric Front Seats | Electric Front Seats |
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| Heated Front Seats | Heated Front Seats | Heated Front Seats |
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| Front Seats Memory | Front Seats Memory | Front Seats Memory— |
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| Ambient Lighting | Ambient Lighting | Ambient Lighting— |
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| Front centre armrest | Front centre armrest | Front centre armrest— |
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| Equipment · Multimedia5 · 4 |
| Touchscreen Display | Touchscreen Display | Touchscreen Display |
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| Apple CarPlay | Apple CarPlay— | Apple CarPlay |
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| Android Auto | Android Auto— | Android Auto |
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| Bluetooth | Bluetooth | Bluetooth— |
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| USB Port | USB Port | USB Port— |
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| Navigation System | Navigation System | Navigation System |
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| AUX input | AUX input | AUX input— |
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| Equipment · Visibility & lights1 · 1 |
| LED Headlights | LED Headlights | LED Headlights |
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| Equipment · Safety9 · 10 |
| Driver's Airbag | Driver's Airbag | Driver's Airbag |
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| Front Passenger Airbag | Front Passenger Airbag | Front Passenger Airbag |
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| Front Side Airbags | Front Side Airbags | Front Side Airbags |
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| Curtain Airbags | Curtain Airbags | Curtain Airbags |
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| Autonomous Emergency Braking | Autonomous Emergency Braking | Autonomous Emergency Braking |
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| Lane Keeping Assist | Lane Keeping Assist | Lane Keeping Assist |
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| Brake assist (BAS) | Brake assist (BAS) | Brake assist (BAS) |
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| ABS | ABS | ABS |
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| Electronic Stability Control (ESP) | Electronic Stability Control (ESP) | Electronic Stability Control (ESP) |
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| Tyre Pressure Monitoring | Tyre Pressure Monitoring— | Tyre Pressure Monitoring |
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| Equipment · Anti-theft2 · 2 |
| Alarm | Alarm | Alarm— |
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| Central Locking | Central Locking | Central Locking |
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| Immobilizer | Immobilizer— | Immobilizer |
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| Equipment · Exterior1 · 0 |
| Alloy Wheels | Alloy Wheels | Alloy Wheels— |
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| On Autodrom now |
| Listings | Listings0 | Listings0 |
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